Post-pandemic global political dynamics are creating significant changes in various aspects of international relations. With the end of the critical phase of COVID-19, countries around the world are starting to adjust their foreign and domestic policies. One of the biggest trends is increasing nationalism and economic protectionism. Many countries are strengthening policies to protect local industries, reduce dependence on international supply chains, and increase economic resilience. Virtual meetings between world leaders during the pandemic gave way to digital diplomacy, which is now known to be the new norm. However, despite this, face-to-face meetings remain important for building trust and cooperation between countries. International forums such as the G20 and ASEAN are now deemed to need to carry out reforms to improve their response to the global crisis, as well as to face increasingly pressing climate and public health issues. Issues of global health and vaccine supply also dominate the post-pandemic political narrative. Countries capable of producing vaccines are trying to strengthen their position on the international stage through vaccine sharing initiatives. Inequalities in vaccine distribution between developed and developing countries create new tensions and threaten global stability. In Asia Pacific, competition between the US and China is increasingly striking. The US is trying to strengthen alliances with allied countries, while China is intensifying diplomatic and economic ties with developing countries, offering help investing in infrastructure. Tensions in the South China Sea and issues related to human rights are becoming an increasingly pressing focus of attention for these two great powers. In Europe, Brexit and growing populism are dragging the European Union into new challenges. The desire of some member states to gain greater control over migration and economic policies is creating divisions. Also, the shift towards renewable energy in response to the climate crisis is also influencing European foreign policy, encouraging international collaboration in this sector. In the Middle East, the post-pandemic impact is visible in reconciliation efforts between countries, especially among the Gulf countries. Meanwhile, the conflicts in Syria and Yemen remain major challenges with chronic humanitarian impacts. The rise of new political movements and militias will continue to influence regional stability. In addition, the issue of climate change is a top priority for many countries in determining their foreign policies. Discussions about carbon emissions and environmental sustainability are driving multi-national cooperation. Countries are now collaborating more frequently on green technologies to address increasingly pressing environmental problems. Social transformation, resulting from the pandemic, has also changed domestic political dynamics in many countries. People who are increasingly connected through social media are more encouraged to participate in government. This creates challenges for a government that is less responsive to the needs of the people, where protests and social movements are increasingly widespread. Resurgent issues of privacy, civil liberties, and human rights emerge in the context of widespread digital surveillance. States must confront the question of how far they can ensure security while respecting individual freedoms. The overall dynamics of post-pandemic global politics demonstrate the complexity in international relations and the desire to adapt to new challenges. Given the interaction between economic, social and technological factors, the future of international relations will depend largely on how countries manage their dependence on each other amidst rapid change.